ASA | Life at The Extremes – trials on Everest & adapting to hypoxia
A discussion about oxygen and the Xtreme Everest research studies into human adaptation to hypoxia. How does the human body adapt to extreme conditions? We assume it will inevitably cause damage but this is not always the case. How do people who have inherited a tolerance for low levels of oxygen manage? Monty Mythen, Mike Grocott and Joff Lacey are joined by special guest Dr Dan Martin OBE, Consultant in Intensive Care and Everest summiteer.
Xtreme Everest Extra | Hypoxia and the Brain
This special four part series explores the fascinating story of Xtreme Everest – the ground-breaking, research programme that has pursued a novel approach to scientific exploration. Over the last decade, this innovative team has performed large scale studies at high altitude to mimic some of the effects of critical illness. The objective is for their findings to be brought “from the mountainside to the bedside” so that the care for our sickest patients may be improved. In this podcast, Chris Imray, describes the physiological changes within the brain when exposed to the hypoxic conditions of high altitude and how our understanding of this may change the management of patients. Presented by Joff Lacey with his guest Chris Imray, a Consultant Vascular Surgeon at University Hospitals Coventry and Warwickshire NHS Trust and a Professor at Warwick Medical School. Chris is a passionate climber and has long been involved in altitude research. He was the deputy climbing leader for the 2007 Xtreme Everest expedition and was part of the summit team.
Xtreme Everest Extra | Unlocking the Secrets of the Mighty Mitochondria
This special four part series explores the fascinating story of Xtreme Everest – the ground-breaking, research programme that has pursued a novel approach to scientific exploration. Over the last decade, this innovative team has performed large scale studies at high altitude to mimic some of the effects of critical illness. The objective is for their findings to be brought “from the mountainside to the bedside” so that the care for our sickest patients may be improved. In this podcast, Andrew Murray, discusses the findings from his studies on Everest in which he has investigated novel mechanisms that control mitochondrial function under hypoxic conditions. It is hoped that his discoveries will facilitate major breakthroughs in tailoring medical interventions to improve the outcome of critical care patients. Presented by Joff Lacey with his guest; Andrew Murray a reader in metabolic physiology at the University of Cambridge. Since 2005, Andrew has been a member of the Xtreme Everest research group, studying mitochondrial function in cardiac and skeletal muscle at high altitude.
Xtreme Everest Extra | The Significance of the Microcirculation
This special four part series explores the fascinating story of Xtreme Everest – the ground-breaking, research programme that has pursued a novel approach to scientific exploration. Over the last decade, this innovative team has performed large scale studies at high altitude to mimic some of the effects of critical illness. The objective is for their findings to be brought “from the mountainside to the bedside” so that the care for our sickest patients may be improved. In this podcast, Dan Martin, explains the fascinating discoveries that his team have made about the microcirculation and how it may adapt to the challenge of hypoxia. Alterations to the microcirculation may be instrumental in the body’s ability to cope under hypoxic conditions and could be become a target for interventions in critical illness. Dan Martin is a reader in perioperative and critical care medicine at UCL and consultant in critical care at the Royal Free Hospital in London. He was the research lead for Xtreme Everest in 2007 and expedition lead in 2013.
Xtreme Everest Extra | The Problem with Hypoxia – the inception of Xtreme Everest
This special four part series explores the fascinating story of Xtreme Everest – the ground-breaking, research programme that has pursued a novel approach to scientific exploration. Over the last decade, this innovative team has performed large scale studies at high altitude to mimic some of the effects of critical illness. The objective is for their findings to be brought “from the mountainside to the bedside” so that the care for our sickest patients may be improved. In this podcast, Denny Levett explains the complex and unpredictable nature of hypoxia, its prevalence in critical care and why there was the scientific demand to head to the world’s highest mountain in search of answers to this clinical challenge. Presented by Joff Lacey with his guest Denny Levett, a consultant in perioperative medicine and critical care at Southampton University Hospital and deputy research leader for the Xtreme Everest expedition in 2007.
Kevin Fong, broadcaster and medical practitioner | WCA 2024
Listen now as we speak about space exploration, a media career which extends to both television, radio and podcasting. We get into AI, medical safety, the oft made comparison with aviation and the ultimate role of humans and machines in complex systems. This piece was recorded and sent to you directly from The 18th WFSA World Congress of Anaesthesiologists in Singapore. Here we have Desiree Chappell and Monty Mythen speaking with Kevin Fong, OBE MRCP FRCA, a well known British doctor and broadcaster; a consultant anaesthetist and anaesthetic lead for Major Incident Planning at University College London Hospitals and a professor (also at UCL) where he organises and runs an undergraduate course Extreme Environment Physiology. As mentioned here is a link to the excellent new BBC radio series: https://www.bbc.co.uk/programmes/m001wjf8 You can find our guest’s insightful Twitter feed here: Dr Kevin Fong (@kevin_fong) / X (twitter.com)
Limitless: From Dingle to Cape Horn, finding my true north in the earth’s vastest oceans | Dingle 2023
“We do need to give ourselves credit for the sacrifices we made along the way…” This entertaining piece is a conversation about blood pressure, swimming, extreme physiology and the joy of exercise. You will hear Desiree Chappell and Monty Mythen chatting with Nuala Moore, an Irish swimmer known for open water swimming and ice swimming. She was the 2011 winner of the Margaret Smith Award of the Irish Long Distance Swimming Association, given for increasing the profile of open water swimming; in 2006, she was one of six swimmers to swim around the coast of Ireland in a relay, the first-ever swim of over 1300 km around the coast. Then in 2008 she did a double relay crossing of the English Channel. Her book “Limitless: From Dingle to Cape Horn, finding my true north in the earth’s vastest oceans” is available to buy in Dingle, or on Amazon: https://amzn.eu/d/bTEBKNS
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Regular Voices
Regular Voices Sol Aronson Regular voice on TopMedTalk Solomon Aronson is a tenured Professor at Duke University and Executive Vice Chairman in the Department of Anaesthesiology. Vicki Morton Regular voice […]
Anchors
Anchors Desirée Chappell Anchor and Co-Editor in Chief Co-Editor in Chief of TopMedTalk and VP of Clinical Quality at NorthStar Anesthesia. Mike Grocott Anchor and Co-Editor in Chief Professor of […]