Andy Cumpstey and Kate Leslie at the American Society of Anesthesiologists (ASA) Annual Meeting in San Antonio, Texas.

They interview Peter Nagele, professor of anesthesiology at the University of Chicago, about his groundbreaking trial on the use of nitrous oxide as a treatment for severe depression. The trial aimed to assess the efficacy of nitrous oxide compared to a placebo and explored different doses (25% vs. 50%). They discusses the study’s promising results, the neurobiology of depression, and the potential for a phase three international multicenter trial.

This episode also highlights the need for novel treatments for treatment-resistant depression and the importance of collaborative research in advancing medical knowledge.